Category: National

More than 5 million people worldwide have had their lives cut short by COVID-19, and the number keeps rising as many countries experience another wave of transmission.

The best defense against this disease is a vaccine, experts say.

Since the outbreak was first reported in 2019, the best scientists all over the world have been working on a vaccine to protect against SARS CoV 2, the virus that causes COVID-19. The acronym stands for “severe acute respiratory syndrome coronavirus 2” to distinguish it from the first SARS outbreak in 2003.

Historically, when scientists make vaccines, they have used a live virus that is so weak it can’t reproduce, or they use a dead virus. When these weakened or inactive viruses are injected into the body, the body recognizes them as intruders, produces antibodies and fights them off.

Polio vaccines have used both weakened live viruses as well as dead ones with enormous success. The Global Polio Eradication Initiative reports that polio cases were reduced by 99.9% between 1988, when the global effort to eliminate polio was started, and 2021. The U.S. Centers for Disease Control and Prevention reports that without the global polio vaccination program, more than 18 million people who are currently healthy would have been paralyzed by the virus.

As of December 6, three children in the entire world have contracted the wild polio virus in 2021.

Three of the vaccines developed against COVID-19 are vector vaccines. A vector is simply a delivery system. In this case, scientists use an adenovirus — a cold virus, for example — to deliver a fragment of the coronavirus. The fragment is a gene from a spike on the crown of the coronavirus. This trains the body to fight off any other similar infections, including COVID-19.

The spike cannot infect someone with the coronavirus.

The Oxford-AstraZeneca vaccine uses a chimpanzee virus, not a human one. The Johnson & Johnson and Sputnik V vaccines use human adenoviruses. J&J uses a rare adenovirus. Sputnik V uses the same virus in its first dose. In its second dose, Sputnik V uses a common adenovirus that some people might be immune to. For this reason, many scientists are concerned that Sputnik V may not be an effective vaccine.

Once injected, the viruses enter the cells and start to produce the spike protein, but not COVID-19. Then, the body mounts an attack.

Dr. Andrea Cox, a professor with a specialty in immunology at the Johns Hopkins University School of Medicine, says our bodies don’t just mount an immune response to the adenovirus, but they also produce an immune response to the spike protein from the coronavirus. In this way, the body learns to fight off the coronavirus if it sees it again.

The World Health Organization has authorized use of the AstraZeneca and Johnson & Johnson vaccines but not Sputnik V. The WHO says it needs more data from the Sputnik V trials.

Cox says the AstraZeneca and Johnson & Johnson vaccines are preferred because they have been given to hundreds of millions of people worldwide. Scientists have more information about their side effects and their immune responses than Sputnik V’s simply because Sputnik has been used far less frequently and there are fewer international studies that have assessed it.

Another issue with Sputnik V, Cox says, is “that the data are not showing the kinds of efficacy rates that we would like to see in a vaccine.”

Some scientists expect COVID-19 to be with us for three to four years. But even with the best scientists in the world working on vaccines, they are concerned that as the virus continues to infect unvaccinated people and mutate, at some point, the vaccines we have now won’t be able to offer full protection against COVID-19.

Source: Voice of America

Two explosions rocked U.N. camps in the northern Mali city of Gao on Sunday, causing damage but no casualties, AFP journalists at the scene said.

The early morning blasts shook the barracks of the U.N. mission in Mali, called MINUSMA, forcing the occupants to take refuge in shelters for two hours.

The French army reported only material damage, but had no information on the possible perpetrators of the blasts.

MINUSMA spokeswoman Myriam Dessables told AFP that two other camps in the north had been targeted with mortar fire on Saturday, causing no damage.

The latest violence in the West African country comes after 31 people were killed in an attack on Friday by suspected jihadists near the central town of Bandiagara.

Mali has been struggling to contain an Islamist insurgency that first erupted in the north in 2012 and has since claimed thousands of military and civilian lives.

Despite the presence of thousands of French and U.N. troops, the conflict has engulfed central Mali and spread to neighboring Burkina Faso and Niger.

France, the former colonial power in Mali, has said it will reduce its troop numbers in the Sahel.

It also said it is planning to transfer troops from Kidal, Tessalit and Timbuktu to Gao and Menaka, closer to the turbulent “three-borders” zone near Burkina Faso and Niger.

Source: Voice of America

The Botswana scientist who may well have discovered the omicron variant of the coronavirus says he has been on a “roller coaster of emotions,” with the pride of accomplishment followed by dismay over the travel bans immediately slapped on southern African countries.

“Is that how you reward science? By blacklisting countries?” Dr. Sikhulile Moyo, a virologist at the Botswana Harvard AIDS Institute Partnership, said in an interview Thursday with The Associated Press.

“The virus does not know passports, it does not know borders,” he added. “We should not do geopolitics about the virus. … We should be collaborating and understanding.”

Moyo was doing genomic sequencing of COVID-19 samples at his lab in Botswana two weeks ago and noticed three cases that seemed dramatically different, with an unusual pattern showing multiple mutations. He continued studying the results and by early last week, decided to publicly release the data on the internet.

Soon scientists in South Africa said they had made the same findings. And an identical case in Hong Kong was also identified.

A new coronavirus variant had been discovered, and soon the World Health Organization named it omicron. It has now been identified in 38 countries and counting, including much of Western Europe and the United States. And the U.S. and many other nations have imposed flight restrictions to try to contain the emerging threat.

Speaking from his lab in Gaborone, Botswana’s capital, Moyo bristled at being described as the man who first identified omicron.

“Scientists should work together and the ‘who first did that’ syndrome should go. We should all be able to be proud that we all contributed in one way or the other,” said the 48-year-old scientist.

In fact, he noted that the variant was found to be something entirely new only by comparing it to other viruses online in a public database shared by scientists.

“The only way you can really see that you see something new is when you compare with millions of sequences. That’s why you deposit it online,” he said.

The Zimbabwe-born Moyo — who is also a research associate at Harvard’s school of public health, a married father of three, and a gospel singer — expressed pride in the way he and his international colleagues were transparent about their findings and sounded the alarm to the rest of the world.

“We’re excited that we probably gave a warning signal that may have averted many deaths and many infections,” he said.

Omicron startled scientists because it had more than 50 mutations.

“It is a big jump in the evolution of the virus and has many more mutations that we expected,” said Tulio de Oliveira, director of the Center for Epidemic Response and Innovation in South Africa, who taught Moyo when he was earning his Ph.D. in virology from South Africa’s Stellenbosch University.

Little is known about the variant, and the world is watching nervously. It’s not clear if it makes people more seriously ill or can evade the vaccine. But early evidence suggests it might be more contagious and more efficient at re-infecting people who have had a bout with COVID-19.

In the coming weeks, labs around the world will be working to find out what to expect from omicron and just how dangerous it is.

“What is important is collaboration and contribution,” Moyo said. “I think we should value that kind of collaboration because it will generate great science and great contributions. We need each other, and that’s the most important.”

South Africa is seeing a dramatic surge in infections that may be driven by omicron. The country reported more than 16,000 new COVID-19 cases Friday, up from about 200 per day in mid-November.

The number of omicron cases confirmed by genetic sequencing in Botswana has grown to 19, while South Africa has recorded more than 200. So far, most of the cases are in people who did not get vaccinated.

“I have a lot of hope from the data that we see, that those vaccinated should be able to have a lot of protection,” Moyo said. “We should try to encourage as many people to get vaccinated as possible.”

Moyo warned that the world “must go to a mirror and look at themselves” and make sure Africa’s 1.3 billion people are not left behind in the vaccination drive.

He credited earlier research and investment into fighting HIV and AIDS with building Botswana’s capacity for doing genetic sequencing. That made it easier for researchers to switch to working on the coronavirus, he said.

Amid the COVID-19 crisis, Moyo finds some cause for optimism.

“What gives me hope is that the world is now speaking the same language,” said Moyo, explaining that the pandemic has seen a new global commitment to scientific research and surveillance.

He added that the pandemic has also been a wake-up call for Africa.

“I think our policymakers have realized the importance of science, the importance of research,” Moyo said. “I think COVID has magnified, has made us realize that we need to focus on things that are important and invest in our health systems, invest in our primary health care.”

He added: “I think it’s a great lesson for humanity.”

Source: Voice of America